We present a biophysically detailed in silico model of retinal degeneration that simulates the network-level response to both light and electrical stimulation as a function of disease progression.

Brains face the fundamental challenge of extracting relevant information from high-dimensional external stimuli in order to form the neural basis that can guide an organism’s behavior and its interaction with the world. One potential approach to addressing this challenge is to reduce the number of variables required to represent a particular …

To investigate the effect of axonal stimulation on the retinal response, we developed a computational model of a small population of morphologically and biophysically detailed retinal ganglion cells, and simulated their response to epiretinal electrical stimulation. We found that activation thresholds of ganglion cell somas and axons varied …

Using a dimensionality reduction technique known as non-negative matrix factorization, we found that a variety of medial superior temporal (MSTd) neural response properties could be derived from MT-like input features. The responses that emerge from this technique, such as 3D translation and rotation selectivity, spiral tuning, and heading …